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Roche huntington

Arzneimittel, Kosmetik- & Pflegeprodukte bequem und günstig online bestellen. Erleben Sie günstige Preise und viele kostenlose Extras wie Proben & Zeitschriften Kostenlose Lieferung möglic The overall aim is to reduce the production of the mutant huntingtin protein by targeting the huntingtin gene - an area of research that Roche and partner company, Ionis, have led the field in, paving the way with one of the largest phase III trials ever conducted in Huntington's disease

Eine Medizin des Herstellers Roche gegen eine seltene und fortschreitende Gehirnerkrankung wird von der Europäischen Arzneimittel-Agentur beschleunigt für eine Marktzulassung geprüft. 03.08.201 Das seit 2013 von Roche und Ionis Pharmaceuticals gemeinsam entwickelte Antisense-Oligonukleotid RG6042 (Ionis-HTTRx) zur Behandlung der Huntington-Krankheit hat von der europäischen Arzneimittelbehörde EMA den Prioritätsstatus erhalten

Roche im Angebot - Gratis Versand in 24h ab 20

Chorea Huntington ist nicht heilbar, Patienten sterben meist innerhalb von 15 Jahren nach Diagnose-Stellung. Die Therapie zielt auf Symptomlinderung der Hyperkinesien und des Rigors. Roche forscht.. Beim Treffen des Europäischen Huntington-Disease Netzwerks (EHDN), teilte die Firma Roche einige Eckdaten der ersten Entscheidungsstudie zum Huntingtin-Verminderungs-Medikament - RG6042, bisher alsIonis-HTTRx bekannt. Welche Neuigkeiten gibt es Die Huntington-Krankheit (HD) ist eine erbliche, neurodegenerative und letztlich tödliche Krankheit, die verheerende Auswirkungen auf Familien über Generationen hinweg hat Roche in Deutschland: 07.08.2018, Roche-Prüfmedikament RG6042 erhält PRIME-Status von EMA zur Behandlung der Huntington-Krankhei

Huntigton bei Amazon

  1. RG6042, formerly known as IONIS-HTTRx, was initially developed by Ionis Pharmaceuticals and later on acquired by Roche. It was granted orphan drug status in Europe and the U.S. in 2015. (Chugai is a member of the Roche group.
  2. In 2013, an alliance was formed between Roche and Ionis based on the promising technology developed by Ionis. At the end of 2017, Roche took over responsibility for all development and commercial activities related to the Huntington's disease programme
  3. Chorea Huntington wird durch ein bestimmtes Protein, Huntingtin, ausgelöst. Der für Huntingtin codierende Genabschnitt findet sich auf dem kurzen Arm des Chromosoms 4. Von Bedeutung bei der..
  4. Roche will now be responsible for the development and marketing of Ionis Pharmaceuticals ' IONIS-HTTRx after exercising its option to license the investigational drug, designed to treat Huntington's disease (HD). This move follows highly promising results from a Phase 1/2a clinical trial
  5. antvererbt. Der krankheitsverursachende Gendefekt befindet sich im Huntingtin-Gen (HTT) auf Chromosom4 (4 p 16.3)
  6. Chorea Huntington (Huntington-Krankheit, veraltet: Veitstanz) ist eine Erkrankung des Gehirns, die vererbt wird. Bei Menschen mit Chorea Huntington werde Bereiche des Gehirns nach und nach zerstört, die für die Steuerung der Muskeln und für psychische Funktionen wichtig ist. Die Nervenzellen gehen langsam zugrunde
  7. Roche and Genentech do not support, endorse or recommend the unapproved use of any compound or service in your jurisdiction, including those discussed on this website. Please refer to local product information for any medicinal products mentioned. Information available on this website does not constitute professional medical advice, and Roche and Genentech accept no responsibility for access.

In December 2017, Roche licensed IONIS-HTT RX from Ionis, renaming it RG6042. The therapy is designed to target the underlying cause of Huntington's disease (HD) by decreasing production of the toxic mutant huntingtin protein (mHTT). The first patient enrolled in the trial on January 28, 2019 April 8, 2013 Roche and Isis Pharmaceuticals form alliance for Huntington's disease. Basel, Switzerland and Carlsbad, CA, USA. Roche (SIX: RO, ROG; OTCQX: RHHBY) and Isis Pharmaceuticals, Inc (NASDAQ: ISIS) today announced that they have formed an alliance to develop treatments for Huntington's disease (HD) based on Isis' antisense oligonucleotide (ASO) technology Die Huntington-Krankheit ist eine seltene, vererbbare Erkrankung, die einen fortschreitenden Abbau von Nervenzellen im Gehirn verursacht. Die Symptome treten typischerweise im Alter zwischen 30 und 50 Jahren auf. In seltenen Fällen kann sie auch in der Jugend oder im höheren Alter auftreten Aktien » Nachrichten » ROCHE HOLDING AG GS » F. Hoffmann-La Roche Ltd: First half of the year with 1%1 growth at constant exchange rates, significant impact of COVID-19 pandemi BASEL, Switzerland, and CARLSBAD, Calif., April 8, 2013 /PRNewswire/ -- Roche (SIX: RO, ROG; OTCQX: RHHBY) and Isis Pharmaceuticals, Inc (NASDAQ: ISIS) today announced that they have formed an alliance to develop treatments for Huntington 's disease (HD) based on Isis' antisense oligonucleotide (ASO) technology. This alliance combines Isis' antisense expertise with Roche 's scientific.

Xconomy San Diego — . A 20-patient Phase 1 study of an RNA drug discovered by Ionis Pharmaceuticals that is being tested as a treatment for Huntington's disease by Roche was suspended after. Roche restarts redesigned Phase 3 Huntington's disease trial Three months after announcing it would reduce dosing in its historic Phase 3 Huntington's disease clinical trial - and pausing for a reset - pharma giant Roche announced on June 20 that it has reopened recruitment for the study, known as GENERATION HD1. GENERATION HD1 aims to measure whether Roche's gene-silencing drug. Gehirn eines an Huntington erkrankten Patienten: Die braunen und rötlichen Bereiche zeigen den Verlust der Hirnmasse Roche gibt Details ihrer ausschlaggebenden Huntingtin-Verminderungsstudie bekannt Die GENERATION-HD1-Studie wird erproben ob das Medikament RG6042 - vormals Ionis- HTTRx - das Fortschreiten der Huntington-Krankheit verlangsamt. Von Dr Jeff Carroll 22. September 2018 Bearbeitet von Dr Ed Wild Übersetzt von Rebecca Ursprünglich veröffentlicht am 17. September 2018 s ist die Zeit der großen. Zum ersten Mal hat ein Medikament den Ausbruch der Huntington-Krankheit verlangsamt. Wissenschaftler sprechen von einem medizinischen Durchbruch. Im Gehir

Roche - Hunting for solution

Huntington-Krankheit: Roche-Mittel wird beschleunigt auf

Huntington's disease is a progressive neurodegenerative disorder inherited as an autosomal-dominant trait, with onset typically occurring in mid-adult life and characterized by movement disorder. Roche bought into Ionis' Huntington's disease program in 2013, and the companies have begun testing the highest dose of RG6042 in a larger Phase 3 study. That study will assess the therapy in a slightly broader group of patients than the Phase 1/2 trial, and aims to recruit 660 patients. The first was enrolled in January this year, triggering a. Roche will ein tieferes Verständnis für diesen Biomarker entwickeln und die Wechselwirkungen zwischen NFL und Huntingtin verstehen. Netterweise stellt Schobel seine Folien uns online zur Verfügung! Es gab sehr wenige Teilnehmer, die die Studie von Roche abbrechen mussten, die ganze Huntington-Gemeinschaft ist den Teilnehmern aller genannten Studien ewig dankbar! Damit verabschieden wir uns. Roche has now tak­en con­trol of the drug and is re­spon­si­ble for mount­ing a piv­otal tri­al. Sarah Tabrizi. Roche first signed on to work with Io­n­is on this drug back in 2013. Io.

Roches Huntington-Kandidat auf Überholspur - transkrip

Roche verfügt über mehr als zehn in der Entwicklung befindliche Prüfpräparate für Krankheiten wie Multiple Sklerose, Spinale Muskelatrophie, Neuromyelitis-Optica-Spektrum-Erkrankungen, Alzheimer, Huntington, Parkinson und Autismus. Über Roche Roche ist ein globales Unternehmen mit Vorreiterrolle in der Erforschung und Entwicklung von Medikamenten und Diagnostika und ist darauf fokussiert. A phase III trial of Roche and Ionis's RG6042 is recruiting patients with Huntington disease (HD) to test whether a gene-silencing drug can slow the progression of a neurodegenerative disease Ionis Pharmaceuticals has shared data from a phase 1/2 trial of its Roche-partnered treatment for Huntington's disease. The small trial linked the two highest doses of antisense drug RG6042 to a.

Wave tested Huntington's patients at doses of 2, 4, 8 and 16 mg, and found an average reduction of mutant protein of 12.4% in cerebrospinal fluid across the 27 patients exposed to the drug at all doses when compared to placebo. Patients taking placebo saw their mutant protein levels rise 10%. A further analysis revealed a statistically larger reduction in harmful protein at the 16 mg dose, but. Aktuelles Stellenangebot als MSL oder Patient Partnership Manager als Rare Conditions Partner(m/w/d) Huntington Disease; Region: DACH; Befristet bis 30.09.2022 in Grenzach bei der Firma Roche Pharma A

Roche is currently developing RG6042, a RNA antisense drug, that can reduce the synthesis of the Huntington protein and thereby, reduce its toxic effects in the brain. At the AAN meeting, Roche presented 9-month data from the on-going open label study involving RG6024 in people with Huntington's disease. Dr. Schobel said, Those results. Inhalt Chorea Huntington - Veitstanz - Forscher entwickeln Wirkstoff gegen Nervenkrankheit. Allein in der Schweiz hoffen rund 400 von Chorea Huntington betroffene Menschen auf ein wirksames. In interactions with the Huntington's community, Roche have learned the importance of testing both doses while acknowledging that less-frequent dosing wouldn't be as demanding for patients, families and the overall healthcare system in a real-world setting. More confidence - Prior to GENERATION HD1, a study of this size involving investigational medicine administered via injection to the. Since 1999, the Huntington's Disease Society of America has committed more than $20 million to fund research, with the goal of finding effective treatments to slow Huntington's disease. Our research efforts have helped to increase the number of scientists working on HD and have shed light on many of the complex biological mechanisms involved

Chorea Huntington: EMA: Fokus auf neuem Huntington-Wirkstof

On Thursday, March 21 st, Roche/Genentech released a Community Statement about changes to the GENERATION-HD1 study, the clinical trial testing huntingtin-lowering drug RG6042. Essentially, they have decided to change the protocol to make it less taxing for families and health professionals: participants will have lumbar punctures (spinal taps) to receive the drug every other month instead of. Roche will keep a record of the personal data that you provide for the minimum period necessary for the purpose of responding to your inquiry, to follow up on such requests and maintain the information in a Medical Information database for reference

Today's top 28 Roche jobs in Huntington, West Virginia, United States. Leverage your professional network, and get hired. New Roche jobs added daily Am Sonntag, 16. September kündigte der Pharmahersteller Roche die Phase 3 Studie zur Prüfung der Wirksamkeit deren Medikament zur Absenkung des Huntingtin-Proteins an. Diese Studie wird an Huntington-Betroffenen (Personen im frühen Stadium der Erkrankung, mit ersten Symptomen) an ca. 90 Standorten weltweit und in 15 Ländern durchgeführt - welche steht noch nicht fest, aber Deutschland. Die Chorea Huntington, auch als Huntingtonsche Chorea oder Huntington-Krankheit bezeichnet (ältere Namen: Veitstanz, großer Veitstanz, Chorea major), ist eine bis heute unheilbare erbliche Erkrankung des Gehirns, die typischerweise durch unwillkürliche, unkoordinierte Bewegungen bei gleichzeitig schlaffem Muskeltonus gekennzeichnet ist. Oft wird sie mit HD abgekürzt, was für. Information von Roche: Änderung des Studiendesigns der Phase-III-Studie GENERATION HD1 zu RG6042 . 3. April 2019 - 19:54-- Michaela Winkelmann. Heute erhielt die Deutsche Huntington-Hilfe e.V. einen Brief von Roche mit den kürzlich bekannt gegebenen Änderungen des Studiendesigns - auf Deutsch. Hier der Link zum Brief. Forschung; Leben mit Huntington; Therapie; Was ist Huntington; Jugend.

Nervenkrankheit Huntington : Wie die Medizin gegen das langsame Absterben des Gehirns kämpft. Wegen einer defekten Erbanlage vergiftet der Körper das Gehirn. Nun scheint die erste Therapie gegen. A Study to Investigate the Pharmacokinetics and Pharmacodynamics of RO7234292 (RG6042) in CSF and Plasma, and Safety and Tolerability Following Intrathecal Administration in Patients With Huntington's Disease - Full Text View 30 Roche St , Huntington, IN 46750-2117 is currently not for sale. The 2,167 sq. ft. single-family home is a 5 bed, 1.5 bath property. This home was built in 1900 and last sold on for. View more property details, sales history and Zestimate data on Zillow Bei Krankheiten wie Muskelschwund und Chorea Huntington wissen wir mittlerweile ziemlich genau, wo wir ansetzen müssen. Anders bei Alzheimer oder Autismus: Dort akzeptieren wir ein Risiko, das sehr hoch ist. Viele Pharmaunternehmen haben die Alzheimerforschung aufgegeben. Wir haben vermutlich die aussichtsreichste Position der Branche. Wir bleiben dran. Wird Roche in zehn oder zwanzig Jahren. Update on Huntington's Program and Clinical Trials from Roche/Genentech Huntington's Disease Society of America. Loading... Unsubscribe from Huntington's Disease Society of America? Cancel.

133 Roche St, Huntington, IN 46750 is a 4 bedroom, 1 bathroom, 2,020 sqft single-family home built in 1929. This property is not currently available for sale. The current Trulia Estimate for 133 Roche St is $63,585 Huntington's Disease (HD) What is HD? HD is a rare, fatal, genetic disease that causes the breakdown of nerve cells in the brain over time. HD affects a person's mental, behavioral and physical abilities, including their ability to reason, walk and speak. 1. Who is affected by HD? In the U.S., approximately 40,000 people may have manifest HD and more than 200,000 people at risk of. Lifecycle Leader; Huntington's disease Roche. Jan. 2018 - Heute 2 Jahre 7 Monate. Basel, Switzerland. Genentech. 10 Jahre 8 Monate. Ocrevus Senior Director Of Marketing Genentech. Sep. 2017 - Dez. 2017 4 Monate. South San Francisco. Ocrevus Marketing Director Genentech. März 2015 - Sep. 2017 2 Jahre 7 Monate. South San Francisco, CA . Division Manager Genentech. Juni 2013 - März 2015.

Ionis Pharmaceuticals (NASDAQ:IONS) announces that exclusive licensee Roche (OTCQX:RHHBY) has completed the enrollment of 791 subjects in a Phase 3 clinical trial, GENERATION HD1, evaluating.

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7234292 (ISIS 443139) in Huntington's Disease Patients Who Participated in Prior Investigational Studies of RO7234292 (ISIS 443139) - Full Text View Roche designed the trial to represent the large majority of people with Huntington's, the company has said. It needed participants whose decline could be anticipated so researchers could assess.

Roche gibt Details ihrer ausschlaggebenden Huntingtin

  1. Roche's Genentech is developing Huntington's disease therapy RG6042 and is now enrolling for phase 3 trials. Earlier trials have shown positive results in reducing the production of a mutant.
  2. 34 Roche St , Huntington, IN 46750-2117 is currently not for sale. The 1,976 sq. ft. single-family home is a 3 bed, 1.0 bath property. This home was built in 1900 and last sold on for. View more property details, sales history and Zestimate data on Zillow
  3. Home value report for 34 Roche St, Huntington, IN 46750. View on Homes.com as well as property record details, price history, local schools and refinance offers
  4. Huntington Beach (USA) Genre(s) Hardcore, Anarcho-Punk, Horrorpunk, Death-Rock, Hair Metal: Gründung 1979 Gründungsmitglieder Gesang. Jack Grisham (1978-1983, seit 1999) Gitarre . Ron Emory (1978-1987, seit 1999) Bass. Mike Roche (1978-1990, seit 1999) Schlagzeug. Todd Barnes (1978-1982) Aktuelle Besetzung Gesang. Jack Grisham Gitarre. Ron Emory Bass. Mike Roche Schlagzeug. Antonio.
  5. Roche and Isis Pharmaceuticals have formed an alliance to develop treatments for Huntington's disease (HD) based on Isis' antisense oligonucleotide (ASO) technology

Roche got a boost today in its quest to steer a potentially landmark Huntington's drug through pivotal development. The EMA handed Roche its PRIME designation for RG6042 — once called IONIS. Wave Life Sciences' stock took another plunge after the company reported early results from its Huntington's disease study. Cambridge, MA-based Wave Lif

Was ist die Huntington Erkrankung? - Roche

Aktienempfehlung vom 21.05.19: Die Experten der Deutsche Bank AG bewerten die Aktie von Roche mit Hold Roche and Isis will work collaboratively on the discovery of an antisense drug utilizing Roche's brain shuttle program. If Roche exercises its option, it will be responsible for global. Home value report for 239 Roche St, Huntington, IN 46750. View on Homes.com as well as property record details, price history, local schools and refinance offers Morbus Huntington, die Huntington Krankheit oder einfach nur Veitstanz - die seltene Erbkrankheit hat viele Namen. Bei Menschen, die unter Chorea Huntington leiden, wird das Gehirn mehr und mehr zerstört. Betroffen sind die Bereiche, die für die Steuerung der Muskeln und für die psychischen Funktionen zuständig sind. Die Nervenzellen sterben und die Ursache für diese.

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Roche-Prüfmedikament RG6042 erhält PRIME-Status von EMA

RG6042, Now in Phase 3 Huntington's Trial, Named Orphan

View 24 photos for 200 Roche St, Huntington, IN 46750 a 3 bed, 2 bath, 2,780 Sq. Ft. single family home built in 1925 that sold on 10/23/2009 Roche Avenue, Huntington, YORK 2 Bedroom End of Terrace . Directions Travelling on Huntington Road take the turning onto Bell Farm Avenue bearing left onto Roche Avenue where the property can be identified by our for sale sign. The Area Huntington is ideal for the commuters travelling to York and also the A1237 leading to the A59 or A64. Huntington has a primary school and also Huntington. The European Medicines Agency's PRIME status is analogous to the FDA's Breakthrough Therapy designation

Video: Roche - Elevating the patient voice in Huntington's diseas

Antisense-Therapie schürt Hoffnung bei Chorea Huntington

Huntington's disease was first identified in the US in 1872 by George Huntington, a doctor's son who used to ride with his father on his rounds in Long Island and who recalled coming across. In the next few weeks, Roche/Genentech will start GENERATION-HD1, a phase III trial of RG6042, studying 660 patients ages 25 to 65 with manifest Huntington's disease. Co-primary endpoints include. Antisense Drugs for Huntington's, ALS and Prion Diseases Could Meet the Dire Need for Brain Treatments. A genetic therapy that increases or lowers levels of a protein raises hopes for a. Huntington-Krankheit selbst sowie umfassende Ratschläge für den Alltag mit Huntington-Patienten. Hinweise zur Sicherung finanziel-ler oder sozialer Ansprüche sowie Aufgaben, Möglichkeiten und die Erreichbarkeit unterstützender Organisationen runden den Ratgeber ab. Neben zahlreichen Ergänzungen bestehender Texte wurden u.a. fol- gende Themen in der vorliegenden Auflage neu aufgenommenen. Alle offenen Jobs bei Roche Diagnostics Automation Solutions GmbH auf einen Blick. Übersichtlich und immer aktuell. Schauen Sie vorbei und finden Sie Ihren Job bei Roche Diagnostics Automation Solutions GmbH

Roche Licenses Promising Huntington's Drug Candidate IONIS

Mrs Courtney Jeanne Roche, is a Psychologist - School based in Huntington, New York. Mrs Courtney Jeanne Roche is licensed to practice in New York (license number 1853704) and her current practice location is 39 Newfoundland Ave, Huntington, New York.She can be reached at her office (for appointments etc.) via phone at (631) 368-0193. NPI number for Mrs Courtney Jeanne Roche is 1033553318 and. Timothy J. Roche is listed as a Chief Executive Officer with Frame To Finish Contracting Inc. in New York. The address on file for this person is 69 Evert Street, Huntington_station, NY 11746 in Suffolk County. The company is a New York Domestic Business Corporation, which was filed on November 7, 1991

Chorea Huntington - DocCheck Flexiko

The GENERATION HD1 trial (Global EvaluatioN of Efficacy and Safety of Roche/Genentech AnTIsense OligoNucletide for Huntington's Disease) will evaluate the efficacy and safety of RG6042 in patients with manifest HD over a period of 25 months. Manifest HD describes the stage at which a person begins to see motor symptoms of HD, like chorea, that make day-to-day tasks more difficult View phone numbers, addresses, public records, background check reports and possible arrest records for Michael Roche in Huntington Beach, CA. Whitepages people search is the most trusted directory View 1 photos for 216 Roche St, Huntington, IN 46750 a 4 bed, 2 bath, 2,478 Sq. Ft. single family home built in 1900 Roche Harbor to Huntington Flight Schedule. Scan through flights from Roche Harbor Airport (RCE) to Tri-State/Milton Airport (HTS) for the upcoming week. Sort the list by any column, and click on a dollar sign to see the latest prices available for each flight. Flights.com only offers pricing for airlines that display a check fare on the days of the week each flight is available. A dot.

Chorea Huntington: Ursachen, Symptome, Therapie - NetDokto

Roche zählt weltweit den wichtigsten Playern bei der Sars-CoV-2-Diagnostik. Das Unternehmen kam schon im Januar mit einem ersten Virus-Test auf den Markt, später folgte im April ein Test, der. Roche and Isis Pharmaceuticals form alliance for Huntington's disease. BASEL, Switzerland, and CARLSBAD, Calif., April 8, 2013 -- Roche (SIX: RO, ROG; OTCQX: RHHBY) and Isis Pharmaceuticals, Inc. Roches real estate listings. Search for homes in Roches with HomeFront Realty. Roches estates, condos, town houses, single family homes, foreclosures, apartments and more Im Jahr 2019 investierte Roche CHF 11,7 Milliarden in Forschung und Entwicklung und erzielte einen Umsatz von CHF 61,5 Milliarden. Genentech in den USA gehört vollständig zur Roche-Gruppe. Roche.

Huntington's Disease Neuroscience Roche Medically Globa

Roche hat von der europäischen Gesundheitsbehörde European Medicines Agency (EMA) den sogenannten PRIME-Status für seinen Produktkandidaten RG6042 zur Behandlung der Erbkrankheit Chorea Huntington (Huntington's disease, HD) erhalten.. Wie der Pharmakonzern in seiner Medienmitteilung vom Freitag schreibt, erteilt die Behörde diesen Status für PRIority MEdicines immer dann, wenn es sich. When the groundbreaking results of the Huntingtin lowering trial, IONIS-HTTRx, was announced the European Huntington Association travelled to Basel to meet Roche Pharmaceuticals. Roche have taken over the trial and is now planning the next step. Roche have put together their own team of around 20 people that are working on the Huntingtin lowering trial Pharma giant Roche and its subsidiary Genentech have inked a deal with PicnicHealth, a startup that helps patients access and share their medical records. The real-world evidence deal will allow the pharmaceutical companies to have access to PicnicHealth's set of de-identified patient records in order to gain insights about certain diseases and treatments

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Roche Suspends Early-Stage Huntington's Disease Trial

Roche and Isis Pharmaceuticals form alliance for

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Huntington drug successfully lowers levels of disease-causing protein, study shows Date: May 6, 2019 Source: University of British Columbia Summary Marie Lourdes Roche is listed as a Manager with Sachama, L.L.C. in Louisiana. The address on file for this person is 27 Hardwick Dr, Huntington Station, NY 11746 in Suffolk County. The company is a Louisiana Limited-Liability Company, which was filed on January 10, 2000 Roche's OCREVUS (ocrelizumab) shorter 2-hour infusion time approved in Europe Reduces infusion time to 2 hours from the conventional 3.5 hours for patients with relapsing or primary progressive.

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